KMID : 0620920180500120164
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Experimental & Molecular Medicine 2018 Volume.50 No. 12 p.164 ~ p.164
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Increased ¥á2-6 sialylation of endometrial cells contributes to the development of endometriosis
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Choi Hee-Jin
Chung Tae-Wook Choi Hee-Jung Han Jung-Ho Choi Jung-Hye Kim Cheorl-Ho Ha Ki-Tae
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Abstract
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Endometriosis is a disease characterized by implants of endometrial tissue outside the uterine cavity and is strongly associated with infertility. Focal adhesion of endometrial tissue to the peritoneum is an indication of incipient endometriosis. In this study, we examined the effect of various cytokines that are known to be involved in the pathology of endometriosis on endometrial cell adhesion. Among the investigated cytokines, transforming growth factor-¥â1 (TGF-¥â1) increased adhesion of endometrial cells to the mesothelium through induction of ¥á2-6 sialylation. The expression levels of ¥â-galactoside ¥á2-6 sialyltransferase (ST6Gal) 1 and ST6Gal2 were increased through activation of TGF-¥âRI/SMAD2/3 signaling in endometrial cells. In addition, we discovered that terminal sialic acid glycan epitopes of endometrial cells engage with sialic acid-binding immunoglobulin-like lectin-9 expressed on mesothelial cell surfaces. Interestingly, in an in vivo mouse endometriosis model, inhibition of endogenous sialic acid binding by a NeuAc¥á2-6Gal¥â1-4GlcNAc injection diminished TGF-¥â1-induced formation of endometriosis lesions. Based on these results, we suggest that increased sialylation of endometrial cells by TGF-¥â1 promotes the attachment of endometrium to the peritoneum, encouraging endometriosis outbreaks.
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KEYWORD
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Cell adhesion, Endocrine reproductive disorders, Glycosylation, Mechanisms of disease
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